Potential Combination of Probiotic Lactobacillus reuteri Encapsulated High Internal Phase Emulsion (HIPE)- Alginate and Modulation of Thylakoid-Based Prebiotic Diets: Alternative Prevention Strategies for Atherosclerosis
I Gede Krisna Arim Sadeva, Jennifer Louisa, Putri Ayu Wulandari
Udayana University, Bali, Indonesia
Abstract
Atherosclerosis plays a big role in the pathogenesis underlying several peripheral, cerebral, and coronary vascular diseases, and has one of the highest morbidity and mortality rates in the world. The current preventive interventions, such as the use of orlistat, colestipol, cholestyramine, and statin are not considered as the optimal answer due to its high cost and various side effects. This paper is written to investigate further on the combination of probiotic agent, Lactobacillus reuteri, with lifestyle intervention that is thylakoid diet modulation as a preventive effort of atherosclerosis. Design of the study is in the form of literature review through search of journals and scientific writings through online databases, such as ScienceDirect, Researchgate, and Pubmed using the appropriate keywords. Inclusion criteria being publications in the past 10 years in English or Indonesian.
Based on the result, L. reuteri and thylakoid has antiatherogenic properties through the mechanism of bile-salt hydrolase secretion, immunomodification effects, regulation of cholesterol absorption, short chain fatty acid production, increased antioxidant activity, HMG-CoA reductase inhibition, and regulation of gut microbiota through the prebiotic effects of thylakoid. HIPE-alginate encapsulation is intended to increase viability of probiotics against environmental conditions of the GI tract.
Combination of 0.81 mL/kgWt probiotic L. reuteri thrice a day and 5.6 g prebiotic thylakoid once a day in syrup form for a week to two months, followed by physical activities is known to has a high antiatherogenic potential with minimal side effects, making it a new field of interest in the prevention of atherosclerosis.
Keywords: Atherosklerosis, Lactobacillus reuteri, thylakoid, HIPE-alginate, lifestyle.
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